Recently, Janpanese research team from Ibaraki University and Yokohama National University found a new active ingredient, Eucommicin A, a β-truxinate lignan from Eucommia ulmoides, is a selective inhibitor of cancer stem cells. And according to their research and clinic experiment, eucommicin a could be a very promising ingredient for the new drug.
Eucommicin A, a β-truxinate type dimer of chlorogenic acid, was identified from Eucommia ulmoides.
Eucommicin A exhibited cytotoxicity towards cancer stem cells.
Eucommicin A suppressed tumor sphere formation of cancer stem cells.
Eucommia Ulmoides, DU Zhong General Statement
Cancer stem cells (CSCs) constitute a small population of undifferentiated cells within a tumor that have the ability to self-renew and drive tumor formation, thus behaving as cancer-initiating cancer cells. Therapeutic interventions that eliminate CSCs are necessary to completely cure patients, since CSCs are a crucial source of tumor recurrence and metastasis. An induced CSC-like (iCSCL) model was recently established using induced pluripotent stem cells (iPSCs). In this study, a natural product—eucommicin A—was identified from Eucommia ulmoides leaves by screening for anti-CSC activity using the iCSCL model. Its structure was elucidated by spectroscopic methods as a quinic acid diester of 3,4,3′,4′-tetrahydroxy-β-truxinic acid. Eucommicin A exhibited selective anti-CSC activity and inhibited tumor sphere formation by iCSCL cells. The results of this study suggest that eucommicin A could serve as a lead compound in the development of drugs to abrogate the stemness and self-renewal ability of CSCs.
Eucommia leaf has been used in China for many years, as the eucommia tea. And even more the bark from eucommia ulmoides oliver has been also applied in Chinese Traditional Medicine for thousand years, as a very precious Chinese herb, it has the function of good for kidney and liver, boosting immunity, lowering blood pressure, prevention of miscarriage, and so on.
RD Health Ingredients can offer Eucommia Leaf extract, botanic source eucommia ulmoides oliver, part of used is leaf. You are welcome to review our product info, and we could offer you the customized product to meet your request.